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Trafficking-Competent KCNQ1 Variably Influences the Function of HERG Long QT Alleles
BACKGROUND: Mutations in the KCNQ1 and HERG genes cause the Long QT Syndromes, LQTS1 and LQTS2, due to reductions in the cardiac repolarizing I(Ks) and I(Kr) currents, respectively. It was previously reported that KCNQ1 co-expression modulates HERG function by enhancing membrane expression of HERG,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904856/ https://ncbi.nlm.nih.gov/pubmed/20348026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.03.038 |
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