Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

The study of the chronological life span of Saccharomyces cerevisiae, which measures the survival of populations of non-dividing yeast, has resulted in the identification of homologous genes and pathways that promote aging in organisms ranging from yeast to mammals. Using a competitive genome-wide a...

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Bibliographic Details
Main Authors: Fabrizio, Paola, Hoon, Shawn, Shamalnasab, Mehrnaz, Galbani, Abdulaye, Wei, Min, Giaever, Guri, Nislow, Corey, Longo, Valter D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904796/
https://ncbi.nlm.nih.gov/pubmed/20657825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001024
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