In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia

Regulatory T cells (Tregs) suppress graft-versus-host disease (GVHD) while preserving a beneficial graft-versus-leukemia (GVL) effect. Thus, their use in allogeneic stem cell transplantation (SCT) provides a promising strategy to treat GVHD. However, 3 obstacles prevent their routine use in human cl...

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Hlavní autoři: Choi, Jaebok, Ritchey, Julie, Prior, Julie L., Holt, Matthew, Shannon, William D., Deych, Elena, Piwnica-Worms, David R., DiPersio, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904576/
https://ncbi.nlm.nih.gov/pubmed/20424188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-257253
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