Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides

During its transport to the bacterial surface, the phosphate groups of the lipid A anchor of Escherichia coli and Salmonella lipopolysaccharide are modified by membrane enzymes including ArnT, EptA and LpxT. ArnT and EptA catalyse the periplasmic addition of the positively charged substituents 4-ami...

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Bibliografiska uppgifter
Huvudupphovsmän: Herrera, Carmen M, Hankins, Jessica V, Trent, M Stephen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2010
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904496/
https://ncbi.nlm.nih.gov/pubmed/20384697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07150.x
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