Genome-Wide Mapping Indicates That p73 and p63 Co-Occupy Target Sites and Have Similar DNA-Binding Profiles In Vivo

BACKGROUND: The p53 homologs, p63 and p73, share ∼85% amino acid identity in their DNA-binding domains, but they have distinct biological functions. PRINCIPAL FINDINGS: Using chromatin immunoprecipitation and high-resolution tiling arrays covering the human genome, we identify p73 DNA binding sites...

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Bibliographic Details
Main Authors: Yang, Annie, Zhu, Zhou, Kettenbach, Arminja, Kapranov, Philipp, McKeon, Frank, Gingeras, Thomas R., Struhl, Kevin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904373/
https://ncbi.nlm.nih.gov/pubmed/20644729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011572
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