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The hydrolysis of phosphate diesters in cyclohexane and acetone

The hydrolysis of phosphate diesters is one of the most difficult reactions known. Here we show that in acetone or cyclohexane, at 25 °C, phosphodiesters undergo hydrolysis 5 × 10(5) and 2 × 10(9)-fold more rapidly than in water, respectively, and that this rate enhancement is achieved by lowering t...

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Detalhes bibliográficos
Main Authors: Stockbridge, Randy B., Wolfenden, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904243/
https://ncbi.nlm.nih.gov/pubmed/20448876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc00229a
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