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Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice

Acute pancreatitis is a painful, inflammatory disorder for which adequate treatments are lacking. An early, critical step in its development is the aberrant signaling of Ca(2+) within the pancreatic acinar cell. This Ca(2+) release is modulated by the intracellular Ca(2+) channel the ryanodine recep...

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Autori principali: Orabi, Abrahim I., Shah, Ahsan U., Ahmad, Mahwish U., Choo-Wing, Rayman, Parness, Jerome, Jain, Dhanpat, Bhandari, Vineet, Husain, Sohail Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904115/
https://ncbi.nlm.nih.gov/pubmed/20448143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00498.2009
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