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The Tumor Suppressor Merlin Is Required for Cell Cycle Exit, Terminal Differentiation, and Cell Polarity in the Developing Murine Lens

PURPOSE. Neurofibromatosis type 2 (NF2) is an autosomal-dominant CNS tumor syndrome that affects 1:25,000 children and young adults. More than 50% of NF2 patients also develop posterior subcapsular cataracts (PSCs). The authors deleted Nf2 from the lens to determine its role in fiber cell differenti...

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Bibliografiske detaljer
Main Authors: Wiley, Luke A., Dattilo, Lisa K., Kang, Kai B., Giovannini, Marco, Beebe, David C.
Format: Artigo
Sprog:Inglês
Udgivet: Association for Research in Vision and Ophthalmology, Inc. 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904013/
https://ncbi.nlm.nih.gov/pubmed/20181838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-4371
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