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Identification of the Cu(2+) Binding Sites in the N-Terminal Domain of the Prion Protein by EPR and CD Spectroscopy

Recent evidence indicates that the prion protein (PrP) plays a role in copper metabolism in the central nervous system. The N-terminal region of human PrP contains four sequential copies of the highly conserved octarepeat sequence PHGGGWGQ spanning residues 60–91. This region selectively binds dival...

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Autors principals: Aronoff-Spencer, Eliah, Burns, Colin S., Avdievich, Nikolai I., Gerfen, Gary J., Peisach, Jack, Antholine, William E., Ball, Haydn L., Cohen, Fred E., Prusiner, Stanley B., Millhauser, Glenn L.
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903970/
https://ncbi.nlm.nih.gov/pubmed/11076515
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