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Identification of the Cu(2+) Binding Sites in the N-Terminal Domain of the Prion Protein by EPR and CD Spectroscopy

Recent evidence indicates that the prion protein (PrP) plays a role in copper metabolism in the central nervous system. The N-terminal region of human PrP contains four sequential copies of the highly conserved octarepeat sequence PHGGGWGQ spanning residues 60–91. This region selectively binds dival...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Aronoff-Spencer, Eliah, Burns, Colin S., Avdievich, Nikolai I., Gerfen, Gary J., Peisach, Jack, Antholine, William E., Ball, Haydn L., Cohen, Fred E., Prusiner, Stanley B., Millhauser, Glenn L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903970/
https://ncbi.nlm.nih.gov/pubmed/11076515
Tagiau: Ychwanegu Tag
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