ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets

Sphingosine kinase (SPHK) catalyzes sphingosine 1-phosphate production, promoting cell survival and reducing apoptosis in isolated rat pancreatic islets. Glucose, the primary islet β-cell growth factor and insulin secretagogue, increased islet SPHK activity by 3- to 5-fold following acute (1 h) or p...

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Bibliographic Details
Main Authors: Mastrandrea, L. D., Sessanna, S. M., Del Toro, A., Laychock, S. G.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2010
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903817/
https://ncbi.nlm.nih.gov/pubmed/20371493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M000802
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