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Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria

Mitochondria are the major cellular producers of reactive oxygen species (ROS), and mitochondrial ROS production increases steeply with increased protonmotive force. The uncoupling proteins (UCP1, UCP2 and UCP3) and adenine nucleotide translocase induce proton leak in response to exogenously added f...

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Detalhes bibliográficos
Main Authors: Toime, Laurence J., Brand, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903626/
https://ncbi.nlm.nih.gov/pubmed/20493945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.05.010
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