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Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Enhances Activation of p38 and ERK MAPKs, Increasing Interleukin-6 Synthesis in Airway Epithelial Cells Exposed to Pseudomonas aeruginosa

In cystic fibrosis (CF), the absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) translates into chronic bacterial infection, excessive inflammation, tissue damage, impaired lung function and eventual death. Understanding the mechanisms underlying this vicious circle of...

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Библиографические подробности
Главные авторы: Bérubé, Julie, Roussel, Lucie, Nattagh, Leila, Rousseau, Simon
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903409/
https://ncbi.nlm.nih.gov/pubmed/20460375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098566
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