LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis

LKB1 is a tumor suppressor protein whose loss leads to HIF1α-mediated activation of a proangiogenic program in intestinal polyps. LKB1 is also protein kinase regulator of AMP-activated protein kinase (AMPK) signaling, which is essential for endothelial cell responses to tissue ischemia. To discern w...

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Bibliographic Details
Main Authors: Ohashi, Koji, Ouchi, Noriyuki, Higuchi, Akiko, Shaw, Reuben J., Walsh, Kenneth
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903404/
https://ncbi.nlm.nih.gov/pubmed/20489196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123794
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