Mixed Lineage Kinase-3 Stabilizes and Functionally Cooperates with TRIBBLES-3 to Compromise Mitochondrial Integrity in Cytokine-induced Death of Pancreatic Beta Cells

Mixed lineage kinases (MLKs) have been implicated in cytokine signaling as well as in cell death pathways. Our studies show that MLK3 is activated in leukocyte-infiltrated islets of non-obese diabetic mice and that MLK3 activation compromises mitochondrial integrity and induces apoptosis of beta cel...

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Hlavní autoři: Humphrey, Rohan K., Newcomb, Christina J., Yu, Shu-Mei A., Hao, Ergeng, Yu, Doris, Krajewski, Stan, Du, Keyong, Jhala, Ulupi S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903363/
https://ncbi.nlm.nih.gov/pubmed/20421299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123786
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