Three Arginine Residues within the RGG Box Are Crucial for ICP27 Binding to Herpes Simplex Virus 1 GC-Rich Sequences and for Efficient Viral RNA Export

ICP27 is a multifunctional protein that is required for herpes simplex virus 1 mRNA export. ICP27 interacts with the mRNA export receptor TAP/NXF1 and binds RNA through an RGG box motif. Unlike other RGG box proteins, ICP27 does not bind G-quartet structures but instead binds GC-rich sequences that...

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Bibliographic Details
Main Authors: Corbin-Lickfett, Kara A., Souki, Stuart K., Cocco, Melanie J., Sandri-Goldin, Rozanne M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903288/
https://ncbi.nlm.nih.gov/pubmed/20410270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00509-10
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