Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication

Rotaviruses are a major cause of acute gastroenteritis in children worldwide. Early stages of rotavirus assembly in infected cells occur in viroplasms. Confocal microscopy demonstrated that viroplasms associate with lipids and proteins (perilipin A, ADRP) characteristic of lipid droplets (LDs). LD-a...

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Main Authors: Cheung, Winsome, Gill, Michael, Esposito, Alessandro, Kaminski, Clemens F., Courousse, Nathalie, Chwetzoff, Serge, Trugnan, Germain, Keshavan, Nandita, Lever, Andrew, Desselberger, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903253/
https://ncbi.nlm.nih.gov/pubmed/20335253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01757-09
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