Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to Virulence

Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif. To test the influence of the C-termina...

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Autors principals: Soubies, Sébastien M., Volmer, Christelle, Croville, Guillaume, Loupias, Josianne, Peralta, Brigitte, Costes, Pierrette, Lacroux, Caroline, Guérin, Jean-Luc, Volmer, Romain
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903243/
https://ncbi.nlm.nih.gov/pubmed/20410267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02427-09
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