Activation of PPARα Attenuates IFNγ and IL-1β-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway

The present study demonstrates the effect of fibrates, agonists of PPARα on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-1β (10 ng/ml), IFNγ (10 ng/ml), and TNF-α (10 ng/ml) cause a significant increase of cell proliferatio...

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Autors principals: Lee, Jin-Koo, Seo, Eun-Min, Lee, Sang-Soo, Park, Soo-Hyun, Sim, Yun-Beom, Jung, Jun-Sub, Kim, Seon-Mi, Suh, Hong-Won
Format: Artigo
Idioma:Inglês
Publicat: The Korean Physiological Society and The Korean Society of Pharmacology 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902811/
https://ncbi.nlm.nih.gov/pubmed/20631892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2010.14.3.185
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