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Identification of small molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen
The Category B agents, ricin and shiga toxin (Stx), are RNA N-glycosidases that target a highly conserved adenine residue within the sarcin-ricin loop of eukaryotic 28S ribosomal RNA. In an effort to identify small-molecule inhibitors of these toxins that could serve as lead compounds for potential...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902711/ https://ncbi.nlm.nih.gov/pubmed/20350563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2010.03.016 |
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