Impact of calcium on N1 influenza neuraminidase dynamics and binding free energy

The highly pathogenic influenza strains H5N1 and H1N1 are currently treated with inhibitors of the viral surface protein neuraminidase (N1). Crystal structures of N1 indicate a conserved, high affinity calcium binding site located near the active site. The specific role of this calcium in the enzyme...

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Bibliografske podrobnosti
Main Authors: Lawrenz, Morgan, Wereszczynski, Jeff, Amaro, Rommie, Walker, Ross, Roitberg, Adrian, McCammon, J Andrew
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2010
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902668/
https://ncbi.nlm.nih.gov/pubmed/20602360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22761
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