Mutagenesis of human DNA polymerase λ: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities

DNA polymerase (pol) λ is homologous to pol β and has intrinsic polymerase and terminal transferase activities. However, nothing is known about the amino acid residues involved in these activites. In order to precisely define the nucleotide-binding site of human pol λ, we have mutagenised two amino...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Shevelev, Igor, Blanca, Giuseppina, Villani, Giuseppe, Ramadan, Kristijan, Spadari, Silvio, Hübscher, Ulrich, Maga, Giovanni
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC290264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14627824/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg896
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