Matrix Metalloproteinase-3 In Articular Cartilage Is Upregulated By Joint Immobilization And Suppressed By Passive Joint Motion

Both underloading and overloading of joints can lead to articular cartilage degradation, a process mediated in part by matrix metalloproteinases (MMPs). Here we examine the effects of reduced loading of rat hindlimbs on articular cartilage expression of MMP-3, which not only digests matrix component...

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Bibliografiske detaljer
Main Authors: Leong, Daniel J, Gu, Xiang I, Li, Yonghui, Lee, Jonathan Y, Laudier, Damien M, Majeska, Robert J, Schaffler, Mitchell B, Cardoso, Luis, Sun, Hui B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902573/
https://ncbi.nlm.nih.gov/pubmed/20153826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.02.004
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