Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor

The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control1. With prevalent hyper-activation of the mTOR pathway in human cancers2, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based platform to identify small-molecule enhancers o...

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Hoofdauteurs: Aghajanyy, Mariam, Jonai, Nao, Flick, Karin, Fu, Fei, Luo, Manlin, Cai, Xiaolu, Ouni, Ikram, Pierce, Nathan, Tang, Xiaobo, Lomenick, Brett, Damoiseaux, Robert, Hao, Rui, del Moral, Pierre M., Verma, Rati, Li, Ying, Li, Cheng, Houk, Kendall N., Jung, Michael E., Zheng, Ning, Huang, Lan, Deshaies, Raymond J., Kaiser, Peter, Huang, Jing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902569/
https://ncbi.nlm.nih.gov/pubmed/20581845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1645
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