Ribavirin improves early responses to peginterferon through enhanced interferon signaling

BACKGROUND & AIMS: The therapeutic mechanisms of ribavirin for hepatitis C are unclear. Microarray analyses have shown that ribavirin increases induction of interferon-stimulated genes (ISGs). We evaluated viral kinetics, serum cytokine expression, and viral mutagenesis during early stages of pe...

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Detalhes bibliográficos
Main Authors: Feld, Jordan J., Lutchman, Glen A., Heller, Theo, Hara, Koji, Pfeiffer, Julie K., Leff, Richard D, Meek, Claudia, Rivera, Maria, Ko, Myung, Koh, Christopher, Rotman, Yaron, Ghany, Marc G., Haynes-Williams, Vanessa, Neumann, Avidan U., Liang, T. Jake, Hoofnagle, Jay H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902566/
https://ncbi.nlm.nih.gov/pubmed/20303352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.03.037
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