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Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
Uptake of the anticancer drug cisplatin is mediated by the copper transporter Ctr1 in cultured cells. Here we show in human ovarian tumors that low levels of Ctr1 mRNA are associated with poor clinical response to platinum-based therapy. Using a mouse model of human cervical cancer, we demonstrate t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902369/ https://ncbi.nlm.nih.gov/pubmed/20541702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.04.011 |
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