Preparation and Characterization of Inclusion Complexes of a Hemisuccinate Ester Prodrug of Δ(9)-Tetrahydrocannabinol with Modified Beta-Cyclodextrins

Δ(9)-Tetrahydrocannabinol hemisuccinate (THC-HS), an ester prodrug of Δ(9)-tetrahydrocannabinol (THC) has been investigated for its potential to form inclusion complexes with modified synthetic beta-cyclodextrins (CDs). Phase solubility studies were performed to determine the stoichiometric ratio of...

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Main Authors: Upadhye, Sampada B., Kulkarni, Swapnil J., Majumdar, Soumyajit, Avery, Mitchell A., Gul, Waseem, ElSohly, Mahmoud A., Repka, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902337/
https://ncbi.nlm.nih.gov/pubmed/20333489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9401-4
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