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Gliclazide Microcrystals Prepared by Two Methods of In Situ Micronization: Pharmacokinetic Studies in Diabetic and Normal Rats

The low water-solubility of gliclazide (GL) leads to a low dissolution rate and variable bioavailability. The aim of this study was to investigate the effect of micronization on the absorption and pharmacokinetics of GL after oral administration in rats. GL microcrystals were prepared using solvent-...

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Detalhes bibliográficos
Main Authors: Talari, Roya, Varshosaz, Jaleh, Mostafavi, Saied Abolfazl, Nokhodchi, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902334/
https://ncbi.nlm.nih.gov/pubmed/20443087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9441-9
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