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Enhanced Bioavailability of Buspirone From Reservoir-Based Transdermal Therapeutic System, Optimization of Formulation Employing Box–Behnken Statistical Design

The purpose of the present study was to develop and optimize reservoir-based transdermal therapeutic system (TTS) for buspirone (BUSP), a low bioavailable drug. A three-factor, three-level Box–Behnken design was employed to optimize the TTS. Hydroxypropyl methylcellulose, d-limonene and propylene gl...

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Main Authors: Gannu, Ramesh, Palem, Chinna Reddy, Yamsani, Shravan Kumar, Yamsani, Vamshi Vishnu, Yamsani, Madhusudan Rao
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902306/
https://ncbi.nlm.nih.gov/pubmed/20517714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9451-7
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