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Inhibition of C5a receptor alleviates experimental CNS lupus

To investigate the role of C5a generated on complement activation in brain, the lupus model, MRL/lpr mice were treated with C5a receptor(R) antagonist (ant). Neutrophil infiltration, ICAM, TNF-α and iNOS mRNA expression, neuronal apoptosis and the expression of p-JNK, pSTAT1 and p-Erk were reduced a...

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Detalhes bibliográficos
Main Authors: Jacob, Alexander, Hack, Bradley, Bai, Tao, Brorson, James R., Quigg, Richard J., Alexander, Jessy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902239/
https://ncbi.nlm.nih.gov/pubmed/20207017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.02.011
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