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Inhibition of C5a receptor alleviates experimental CNS lupus
To investigate the role of C5a generated on complement activation in brain, the lupus model, MRL/lpr mice were treated with C5a receptor(R) antagonist (ant). Neutrophil infiltration, ICAM, TNF-α and iNOS mRNA expression, neuronal apoptosis and the expression of p-JNK, pSTAT1 and p-Erk were reduced a...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902239/ https://ncbi.nlm.nih.gov/pubmed/20207017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.02.011 |
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