Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression of CRLF2 (cytokine receptor-like factor 2). Each of the 29 cases harbored a genomic rearrangement of CRLF2: 18 of 29 (...

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Autors principals: Harvey, Richard C., Mullighan, Charles G., Chen, I-Ming, Wharton, Walker, Mikhail, Fady M., Carroll, Andrew J., Kang, Huining, Liu, Wei, Dobbin, Kevin K., Smith, Malcolm A., Carroll, William L., Devidas, Meenakshi, Bowman, W. Paul, Camitta, Bruce M., Reaman, Gregory H., Hunger, Stephen P., Downing, James R., Willman, Cheryl L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902132/
https://ncbi.nlm.nih.gov/pubmed/20139093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-245944
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