Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA

Perturbations in cell-cell contact machinery occur frequently in epithelial cancers and result in increased cancer cell migration and invasion. Previously, we demonstrated that MMP-7, a protease implicated in mammary and intestinal tumor growth, can process the adherens junction component E-cadherin...

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Hauptverfasser: Lynch, Conor C., Vargo-Gogola, Tracy, Matrisian, Lynn M., Fingleton, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902104/
https://ncbi.nlm.nih.gov/pubmed/20628524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/530745
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