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Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site
The unique amino acid hypusine is formed exclusively in eIF5A by the successive action of deoxyhypusine synthase and deoxyhypusine hydroxylase (yeast Lia1, human DOHH). Although the first enzyme has been extensively studied, both Lia1 structure and the mechanism of action remain unclear. Hence, a mu...
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Main Authors: | , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
2009
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901987/ https://ncbi.nlm.nih.gov/pubmed/19956996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-009-0407-8 |
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