In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts

Asbestos-induced mutagenicity in the lung may involve reactive oxygen/nitrogen species (ROS/RNS) released by alveolar macrophages. With the aim of proposing an alternative in vitro mutagenesis test, a coculture system of rat alveolar macrophages (NR8383) and transgenic Big Blue Rat2 embryonic fibrob...

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Detalhes bibliográficos
Main Authors: Guichard, Yves, Gaté, Laurent, Darne, Christian, Bottin, Marie-Claire, Langlais, Cristina, Micillino, Jean-Claude, Goutet, Michèle, Julien, Schmit, Stéphane, Binet
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901601/
https://ncbi.nlm.nih.gov/pubmed/20628587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/323828
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