A Pathologic Cascade Leading to Synaptic Dysfunction in α-Synuclein-Induced Neurodegeneration

Several neurodegenerative diseases are typified by intraneuronal α-synuclein deposits, synaptic dysfunction, and dementia. While even modest α-synuclein elevations can be pathologic, the precise cascade of events induced by excessive α-synuclein and eventually culminating in synaptotoxicity is uncle...

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Autori principali: Scott, David A., Tabarean, Iustin, Tang, Yong, Cartier, Anna, Masliah, Eliezer, Roy, Subhojit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901533/
https://ncbi.nlm.nih.gov/pubmed/20554859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1091-10.2010
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