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Optimization of an Unnatural Base Pair Towards Natural-Like Replication

Predominantly hydrophobic unnatural nucleotides that selectively pair within duplex DNA as well as during polymerase-mediated replication have recently received much attention as the cornerstone of efforts to expand the genetic alphabet. We recently reported the results of a screen and subsequent le...

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Autors principals: Seo, Young Jun, Hwang, Gil Tae, Ordoukhanian, Phillip, Romesberg, Floyd E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901498/
https://ncbi.nlm.nih.gov/pubmed/19256568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807853m
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