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Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs
Here, we report our second-generation synthesis of 12 artificial glutamate analogs, starting from heterotricycle intermediates 3a–3d, readily prepared in three steps including tandem Ugi/Diels-Alder reactions. The new synthesis employs imidate intermediates for the deoxygenation of pyrrolidones (10a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901232/ https://ncbi.nlm.nih.gov/pubmed/20472441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.04.044 |
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