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Tau Ser262 phosphorylation is critical for Aβ42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
The amyloid-β 42 (Aβ42) peptide has been suggested to promote tau phosphorylation and toxicity in Alzheimer's disease (AD) pathogenesis; however, the underlying mechanisms are not fully understood. Using transgenic Drosophila expressing both human Aβ42 and tau, we show here that tau phosphoryla...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901137/ https://ncbi.nlm.nih.gov/pubmed/20466736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq200 |
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