A Facile Iterative Synthesis of 2,5-Terpyrimidinylenes as Non-peptidic α-Helical Mimics

[Image: see text] A facile iterative synthesis of 2,5-terpyrimidinylenes that are structurally analogous to α-helix mimics is presented. Condensation of amidines with readily prepared α,β-unsaturated α-cyanoketones gives 5-cyano substituted pyrimidines. Iterative transformation of the 5-cyano group...

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Main Authors: Anderson, Laura, Zhou, Mingzhou, Sharma, Vasudha, McLaughlin, Jillian M., Santiago, Daniel N., Fronczek, Frank R., Guida, Wayne C., McLaughlin, Mark L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901110/
https://ncbi.nlm.nih.gov/pubmed/20469918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo100272d
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