Th17 Cells Promote Autoimmune Anti-Myeloperoxidase Glomerulonephritis

A major target autoantigen in anti-neutrophil cytoplasmic antibody–associated vasculitis is myeloperoxidase (MPO). Although MPO-specific CD4(+) Th cells seem to orchestrate renal injury, the role of the Th17 subset is unknown. We hypothesized that Th17 cells direct injurious anti-MPO autoimmunity in...

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Main Authors: Gan, Poh-Yi, Steinmetz, Oliver M., Tan, Diana S.Y., O'Sullivan, Kim M., Ooi, Joshua D., Iwakura, Yoichiro, Kitching, A. Richard, Holdsworth, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2010
Assuntos:
Brief Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900960/
https://ncbi.nlm.nih.gov/pubmed/20299361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009070763
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