Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells

MicroRNAs (miRNA), small noncoding RNAs, affect a broad range of biological processes, including tumorigenesis, by targeting gene products that directly regulate cell growth. Human polynucleotide phosphorylase (hPNPase(old-35)), a type I IFN-inducible 3′-5′ exoribonuclease, degrades specific mRNAs a...

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Bibliografische gegevens
Hoofdauteurs: Das, Swadesh K., Sokhi, Upneet K., Bhutia, Sujit K., Azab, Belal, Su, Zhao-zhong, Sarkar, Devanand, Fisher, Paul B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900648/
https://ncbi.nlm.nih.gov/pubmed/20547861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914143107
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