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Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells
MicroRNAs (miRNA), small noncoding RNAs, affect a broad range of biological processes, including tumorigenesis, by targeting gene products that directly regulate cell growth. Human polynucleotide phosphorylase (hPNPase(old-35)), a type I IFN-inducible 3′-5′ exoribonuclease, degrades specific mRNAs a...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900648/ https://ncbi.nlm.nih.gov/pubmed/20547861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914143107 |
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