Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation

In a previous study, we demonstrated that β1,3-N-acetylglucosaminyltransferase 5 (B3gnt5) is a lactotriaosylceramide (Lc(3)Cer) synthase that synthesizes a precursor structure for lacto/neolacto-series glycosphingolipids (GSLs) in in vitro experiments. Here, we generated B3gnt5-deficient (B3gnt5(−/−...

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Detalles Bibliográficos
Main Authors: Togayachi, Akira, Kozono, Yuko, Ikehara, Yuzuru, Ito, Hiromi, Suzuki, Nami, Tsunoda, Yuki, Abe, Sumie, Sato, Takashi, Nakamura, Kyoko, Suzuki, Minoru, Goda, Hatsumi M., Ito, Makoto, Kudo, Takashi, Takahashi, Satoru, Narimatsu, Hisashi
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900644/
https://ncbi.nlm.nih.gov/pubmed/20547865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914298107
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