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Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands

Integrin heterodimers acquire high affinity to endothelial ligands by extensive conformational changes in both their α and β subunits. These heterodimers are maintained in an inactive state by inter-subunit constraints. Changes in the cytoplasmic interface of the integrin heterodimer (referred to as...

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Bibliografiske detaljer
Hovedforfatter: Alon, Ronen
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900616/
https://ncbi.nlm.nih.gov/pubmed/20372052
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