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Novel Alexa Fluor-488 Labeled Antagonist of the A(2A) Adenosine Receptor: Application to a Fluorescence Polarization-Based Receptor Binding Assay

Fluorescence polarization (FP) assay has many advantages over the traditional radioreceptor binding studies. We developed an A(2A) adenosine receptor (AR) FP assay using a newly synthesized fluorescent antagonist of the A(2A)AR (MRS5346), a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine deri...

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Autors principals: Kecskés, Miklós, Kumar, T. Santhosh, Yoo, Lena, Gao, Zhan-Guo, Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900413/
https://ncbi.nlm.nih.gov/pubmed/20438717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.04.027
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