Loading...
Partial Loss of Ataxin-1 Function Contributes to Transcriptional Dysregulation in Spinocerebellar Ataxia Type 1 Pathogenesis
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by expansion of a CAG repeat that encodes a polyglutamine tract in ATAXIN1 (ATXN1). Molecular and genetic data indicate that SCA1 is mainly caused by a gain-of-function mechanism. However, deletion of wil...
Na minha lista:
Main Authors: | , , , , |
---|---|
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Public Library of Science
2010
|
Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900305/ https://ncbi.nlm.nih.gov/pubmed/20628574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001021 |
Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|