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Predicting Important Residues and Interaction Pathways in Proteins Using Gaussian Network Model: Binding and Stability of HLA Proteins

A statistical thermodynamics approach is proposed to determine structurally and functionally important residues in native proteins that are involved in energy exchange with a ligand and other residues along an interaction pathway. The structure-function relationships, ligand binding and allosteric a...

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Autors principals: Haliloglu, Turkan, Gul, Ahmet, Erman, Burak
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900293/
https://ncbi.nlm.nih.gov/pubmed/20628622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000845
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