Effectiveness of Combined Modality Radiotherapy of Orthotopic Human Squamous Cell Carcinomas in Nu/Nu Mice Using Cetuximab, Tirapazamine and MnSOD-Plasmid Liposome Gene Therapy

Hypoxic regions limit the radiocontrollability of head and neck carcinomas. Whether or not combinations of plasmid/liposome mediated overexpression of normal tissue protective manganese superoxide dismutase (MnSOD), cetuximab (C225), and the hypoxic cytotoxin tirapazamine (TPZ) enhanced radiotherape...

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Main Authors: EPPERLY, MICHAEL W., LAI, STEPHEN Y., KANAI, ANTHONY J., MASON, NEAL, LOPRESI, BRIAN, DIXON, TRACEY, FRANICOLA, DARCY, NIU, YUNYUN, WILSON, WILLIAM R., GREENBERGER, JOEL S.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2899489/
https://ncbi.nlm.nih.gov/pubmed/20133969
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