The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3β pathway and β-catenin stability

BACKGROUND: Prostate cancer shows an extremely slow progression, appearing in its metastatic, hormone refractory phenotype mostly in elderly men. The chemopreventive targeting of this tumor could accordingly delay its malignancy over life expectancy. The cancer chemopreventive retinoid N-(4 hydroxyp...

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Hauptverfasser: Benelli, Roberto, Monteghirfo, Stefano, Venè, Roberta, Tosetti, Francesca, Ferrari, Nicoletta
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898704/
https://ncbi.nlm.nih.gov/pubmed/20537156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-142
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