Chronic myeloid leukemia: mechanisms of blastic transformation

The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease usually respond to treatment with ABL tyrosine kinase inhibitors (TKIs), although some patients who respond initially later become r...

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Bibliografiske detaljer
Main Authors: Perrotti, Danilo, Jamieson, Catriona, Goldman, John, Skorski, Tomasz
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Science in Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898591/
https://ncbi.nlm.nih.gov/pubmed/20592475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41246
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